Laryngeal Cancer

Research from Southern General Hospital in laryngeal cancer provides new insights

Published in Cancer Weekly, May 19th, 2009

According to recent research published in the journal Otolaryngology - Head and Neck Surgery, "Centrosome amplification as detected by gamma tubulin (GT) immunostaining is associated with genetic instability and tumor aggressiveness. We assessed GT for its ability to predict recurrence of squamous cell carcinoma of the larynx (SCCL)."

"Case series with chart review. Five micron sections of 35 archival SCCL samples were subjected to antigen retrieval and immunostaining with antibody to GT. The keratin antibody CK5 served as a positive control for antigen retrieval, and tonsillar tissue was used as a negative control. Of the 35 tumors analyzed, 22 were associated...

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Source: Cancer Weekly (2009-05-19)

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