Cancer Weekly
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Adenomatous Polyp
Studies from N. Telang and colleagues yield new information about adenomatous polyp
May 19th, 2009
According to recent research from the United States, "Clinical familial adenomatous polyposis (FAP) syndrome represents a high risk pre-invasive precursor for colon cancer, and is characterized by germ line mutation in the adenomatous polyposis coli (APC) tumor suppressor gene. Cellular models with relevant genetic and biological characteristics should provide important mechanistic leads for predisposition and preventive intervention." "Cloned colon epithelial cell line from the Apc(850) (Min/+) mouse represented a model for FAP. Cell cycle progression, cellular apoptosis and anchorage-independent growth represented the biomarkers for carcinogenic risk. The Apc mutant...
Source: Cancer Weekly (2009-05-19)
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