Cancer Weekly
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Angiogenesis
New angiogenesis research from W.B. Zhu and co-researchers described
May 19th, 2009
"Anaplastic thyroid carcinoma (ATC) is among the most aggressive malignancies known and is characterized with rapid growth, early invasion, and complete refractoriness to current therapies. Here we report that triptolide, a small molecule from a Chinese herb, could potently inhibit proliferation in vitro, angiogenesis in vivo, and invasion in a Matrigel model in human ATC cell line TA-K cells at nanomolar concentrations," scientists in Guangzhou, People's Republic of China report. "We further elucidate that triptolide inhibits the nuclear factor-kappa B(NF kappa B) transcriptional activity via blocking the association of p65 subunit with CREB-binding protein (CBP)/p300...
Source: Cancer Weekly (2009-05-19)
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