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Bladder Cancer
Research results from Columbia University update understanding of bladder cancer
May 19th, 2009
According to a study from the United States, "Although bladder cancer represents a serious health problem worldwide, relevant mouse models for investigating disease progression or therapeutic targets have been lacking. We show that combined deletion of p53 and Pten in bladder epithelium leads to invasive cancer in a novel mouse model." "Inactivation of p53 and PTEN promotes tumorigenesis in human bladder cells and is correlated with poor survival in human tumors. Furthermore, the synergistic effects of p53 and Pten deletion are mediated by deregulation of mammalian target of rapamycin ( mTOR) signaling, consistent with the ability of rapamycin to block bladder...
Source: Cancer Weekly (2009-05-19)
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