New prostate cancer genetics study findings reported from Boston University, Department of Biochemistry

A report, 'Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells,' is newly published data in Oncogene. According to a study from the United States, "AMP-activated protein kinase (AMPK) serves as a fuel-sensing enzyme that is activated by binding of AMP and subsequent phophorylation by upstream kinases such as the tumor suppressor LKB1, when cells sense an increase in the ratio of AMP to ATP. Acute activation of AMPK stimulates fatty acid oxidation to generate more ATP and simultaneously inhibits ATP-consuming processes including fatty acid and protein syntheses, thereby preserving energy for acute cell-surviving program, whereas chronic activation...

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