Cancer Weekly
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Breast Cancer
New breast cancer data have been reported by scientists at University of Nancy
May 19th, 2009
"Alcohol consumption increases the risk of breast cancer but the underlying mechanisms are not well understood. We have shown previously that ethanol activates ER signalling pathway in a cAMP/PKA-mediated ligand-independent manner," scientists writing in the journal Oncology Reports report. "Since the activation of A(2A) adenosine receptor (A(2A)AR) by ethanol has been reported in other cell types, here we tested if cross-talk between this Gs-coupled receptor and ER alpha could be involved in ethanol effects in breast cancer cells. Our study shows that A(2A)AR is expressed and functional in the hormone-dependent breast cancer cell line MCF-7. Interestingly,...
Source: Cancer Weekly (2009-05-19)
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