Cancer Weekly
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Cancer Vaccines
Studies from J. Grunewald and co-researchers update current data on cancer vaccines
May 19th, 2009
"For more than 2 centuries active immunotherapy has been at the forefront of efforts to prevent infectious disease [Waldmann TA (2003) Nat Med 9: 269-277]. However, the decreased ability of the immune system to mount a robust immune response to self-antigens has made it more difficult to generate therapeutic vaccines against cancer or chronic degenerative diseases," scientists in the United States report. "Recently, we showed that the site-specific incorporation of an immunogenic unnatural amino acid into an autologous protein offers a simple and effective approach to overcome self-tolerance. Here, we characterize the nature and durability of the polyclonal IgG antibody...
Source: Cancer Weekly (2009-05-19)
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