Cancer Weekly
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Cancer Vaccines
Study data from Radboud University provide new insights into cancer vaccines
May 26th, 2009
"The success of immunotherapy with dendritic cells (DC) to treat cancer is dependent on effective migration to the lymph nodes and subsequent activation of antigen-specific Tcells. In this study, we investigated the fate of DC after intradermal (i.d.) or intranodal (i.n.) administration and the consequences for the immune activating potential of DC vaccines in melanoma patients," scientists in Netherlands report. "DC were i.d. or i.n. administered to 25 patients with metastatic melanoma scheduled for regional lymph node resection. To track DC in vivo with scintigraphic imaging and in lymph nodes by immunohistochemistry, cells were labeled with both [In-111]-indium and...
Source: Cancer Weekly (2009-05-26)
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