Cancer Weekly
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Acute Lymphoblastic Leukemia
Research on acute lymphoblastic leukemia reported by S.S. Rao et al
May 26th, 2009
"NOTCH signaling is deregulated in the majority of T-cell acute lymphoblastic leukemias (T-ALL) as a result of activating mutations in NOTCH1. Gamma secretase inhibitors (GSI) block proteolytic activation of NOTCH receptors and may provide a targeted therapy for T-ALL," investigators in the United States report. "We have investigated the mechanisms of GSI sensitivity across a panel of T-ALL cell lines, yielding an approach for patient stratification based on pathway activity and also providing a rational combination strategy for enhanced response to GSI. Whereas the NOTCH1 mutation status does not serve as a predictor of GSI sensitivity, a gene expression signature of...
Source: Cancer Weekly (2009-05-26)
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