Cancer Weekly
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Adenomatous Polyposis Coli
Studies from Carnegie Mellon University have provided new data on adenomatous polyposis coli
May 26th, 2009
"The rearrangement of cytoskeletal elements is essential for many cellular processes. The tumor suppressor Adenomatous polyposis coli (APC) affects the function of microtubules and actin, but the mechanisms by which it does so are not well understood," investigators in the United States report. "Here we report that Drosophila syncytial embryos null for Apc2 display defects in the formation and extension of pseudocleavage furrows, which are cortical actin structures important for mitotic fidelity in early embryos. Furthermore, we show that the formin Diaphanous (DIA) functions with APC2 in this process. Colocalization of APC2 and DIA peaks during furrow extension, and...
Source: Cancer Weekly (2009-05-26)
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