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Alzheimer Disease
Research findings from K.A. Sterenczak et al update understanding of Alzheimer disease
May 26th, 2009
According to a study from Hannover, Germany, "RAGE is a member of the immunoglobulin superfamily of cell surface molecules playing key roles in pathophysiological processes, e.g. immune/inflammatory disorders, Alzheimer's disease diabetic arteriosclerosis and tumourigenesis. In humans 19 naturally occurring PAGE splicing variants resulting in either N-terminally or C-terminally truncated proteins were identified and are lately discussed as mechanisms for receptor regulation." "Accordingly, deregulation of sRAGE levels has been associated with several diseases e.g. Alzheimer's disease, Type I diabetes, and rheumatoid arthritis. Administration of recombinant sRAGE to...
Source: Cancer Weekly (2009-05-26)
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