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Cancer Weekly

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Angiogenesis



Researchers from Radboud University provide details of new studies and findings in the area of angiogenesis



May 26th, 2009

According to recent research from Netherlands, "Tumour growth and spread of tumour cells requires angiogenesis. incipient angiogenesis is not induced by turnout cell hypoxia but probably by proangiogenic factors. During growth tumours depend on a further induction of vascular development for adequate oxygen and nutrient supply."

"If the oxygen supply is insufficient, the resulting hypoxia stimulates angiogenesis through upregulation of HIF-1 alpha and VEGF. VEGF upregulation is associated with a poor response to treatment and poor prognosis. The aim of the study was to analyze the interrelationship between hypoxia and angiogenesis during turnout growth. Therefore the...


Source: Cancer Weekly (2009-05-26)

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