Cancer Weekly
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Angiogenesis
Studies in the area of angiogenesis reported from M.M. Neaz and co-researchers
May 26th, 2009
According to recent research from Seoul, South Korea, "The growth and metastasis of solid tumors are dependent on angiogenesis. The vascular endothelial growth factor (VEGF) is of particular interest since it is essential for angiogenesis." "The development of novel inhibitors of VEGF receptor type 2 (VEGFR-2) is important. Quantitative structure-activity relationship (QSAR) studies were performed to understand the structural factors affecting inhibitory potency of 4-aryl-5-cyano-2-aminopyrimidines. Pharmacophore models indicate that the importance of steric and hydrogen bond acceptor groups. The best-fitted pharmacophore-based alignment was used for comparative...
Source: Cancer Weekly (2009-05-26)
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