Cancer Weekly
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Cancer Gene Therapy
Research from Harvard University has provided new data on cancer gene therapy
May 26th, 2009
"Although oncolytic viral vectors show promise for the treatment of various cancers, ineffective initial distribution and propagation throughout the tumor mass often limit the therapeutic response. A mathematical model is developed to describe the spread of herpes simplex virus from the initial injection site," researchers in the United States report. "The tumor is modeled as a sphere of radius R. The model incorporates reversible binding, interstitial diffusion, viral degradation, and internalization and physiologic parameters. Three species are considered as follows: free interstitial virus, virus bound to cell surfaces, and internalized virus. This analysis reveals...
Source: Cancer Weekly (2009-05-26)
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