Cancer Weekly
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Apoptosis
Investigators at Cleveland Clinic release new data on apoptosis
May 26th, 2009
According to recent research from the United States, "We previously elucidated an important role for gangliosides in renal cell carcinoma-mediated T lymphocyte apoptosis, although the mechanism by which they mediated lymphocyte death remained unclear. Here, we show that when added in purified form, GD3 is internalized by activated T cells, initiating a series of proapoptotic events, including the induction of reactive oxygen species (ROS), an enhancement of p53 and Bax accumulation, an increase in mitochondrial permeability, cytochrome c release, and the activation of caspase-9." "GD3-induced apoptosis of activated T cells was dose dependent and inhibitable by...
Source: Cancer Weekly (2009-05-26)
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