Cancer Weekly
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Apoptosis
Study results from J. Yang and colleagues update understanding of apoptosis
May 26th, 2009
"The p53 tumor suppressor protein negatively regulates hypoxia-inducible factor 1 alpha (HIF-1 alpha). Here, we show that induction of p53 by the small-molecule RITA (reactivation of p53 and induction of tumor cell apoptosis) [2,5-bis(5-hydroxymethyl-2-thienyl) furan] (NSC-652287) inhibits HIF-1 alpha and vascular endothelial growth factor expression in vivo and induces significant tumor cell apoptosis in normoxia and hypoxia in p53-positive cells," researchers in London, the United Kingdom report. "RITA has been proposed to stabilize p53 by inhibiting the p53-HDM2 interaction. However, induction of p53 alone was insufficient to block HIF-1 alpha induced in hypoxia and...
Source: Cancer Weekly (2009-05-26)
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