Cancer

New findings reported from University of East Anglia describe advances in cancer

Published in Cancer Weekly, June 2nd, 2009

According to recent research from Norwich, the United Kingdom, "Cyclooxygenase-2 (COX-2) overexpression has been associated with the grade, prognosis and recurrence of transitional cell carcinoma (TCC) of the bladder. In this study, sulforaphane, a dietary isothiocyanate, down-regulated COX-2 expression in human bladder transitional cancer T24 cells at both transcriptional- and translational levels."

"Sulforaphane (5-20 mc M) induced nuclear translocation of NF-kappa B and reduced its binding to the COX-2 promoter, a key mechanism for suppressing COX-2 expression by sulforaphane. Moreover, sulforaphane increased expression of p38 and phosphorylated-p38 protein. A...

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Source: Cancer Weekly (2009-06-02)

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