Cancer
Research results from State University of New York update knowledge of cancer
Published in Cancer Weekly, June 2nd, 2009
" Our objectives were (1) to compare the disposition and in vivo release of paclitaxel between a tocopherol-based Cremophor-free formulation (Tocosol Paclitaxel (R)) and Cremophor (R) EL-formulated paclitaxel (Taxol (R)) in human subjects, and (2) to develop a mechanistic model for unbound and total paclitaxel pharmacokinetics. A total of 35 patients (average +/- SD age: 59 +/- 13 years) with advanced non-hematological malignancies were studied in a randomized two-way crossover trial," scientists writing in the journal Cancer Chemotherapy and Pharmacology report.
"Patients received 175 mg/m(2) paclitaxel as 15 min (Tocosol Paclitaxel) or 3 h (Taxol) intravenous...
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Source: Cancer Weekly (2009-06-02)
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