Newcastle Disease

Research reports on Newcastle disease from C. Pfirschke and colleagues provide new insights

Published in Cancer Weekly, June 2nd, 2009

According to a study from Heidelberg, Germany, "Oncolytic virotherapy, a new type of cancer therapy involving viruses with oncolytic and immunostimulatory potential, is based on tumor selective viral replication, resulting in a specific lysis Of tumor cells. Effective tumor targeting of oncolytic viruses remains a major problem because only a fraction of systemically applied viruses can reach the tumor tissue."

"We describe for the first time in an in vitro CO-Culture system that T lymphocytes can be loaded with Newcastle disease virus (NDV) in such a way that the virus load will be transferred to the tumor target Cells upon contact of the T cells with tumor cells. The...

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Source: Cancer Weekly (2009-06-02)

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