Colon Cancer
Research on colon cancer published by scientists at Vanderbilt University
Published in Cancer Weekly, June 2nd, 2009
According to a study from the United States, "4-Hydroxynonenal (HNE) is a pro-apoptotic electrophile generated during the spontaneous decomposition of oxidized lipids. We have previously shown that HNE activates the transcription factor, heat shock factor 1 (HSF1), and promotes cytoprotective heat shock gene expression and that silencing HSF1 sensitizes the colon cancer cell line RKO to HNE-induced apoptosis."
"Here we report a reduction in the anti-apoptotic proteins Bcl-X-L, Mcl-1, and Bcl-2 in HSF1-silenced RKO cells, and we examine the underlying mechanism. To investigate the regulation of the Bcl-2 family by HSF1, microarray analysis of gene expression was...
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Source: Cancer Weekly (2009-06-02)
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