Fusion Proteins
Study findings from S. Tomblyn et al provide new insights into fusion proteins
Published in Cancer Weekly, June 2nd, 2009
According to a study from the United States, "Previously, prolactin receptor antagonist (G129R)based fusion proteins were developed including G129R fusions with an angiogenesis inhibitor (endostatin), an immune system modulator (interleukin 2), and a modified truncated cytotoxin (PE38KDEL). Each fusion protein was designed to target the PRLR-positive cells via the G129R moiety and at the same time attack a hallmark common to cancer cells via the second moiety."
"In this study, we tested the efficacy of the three fusion proteins as a combination therapy in an aggressive but clinically relevant mouse tumor model. To test the feasibility and to optimize a treatment...
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Source: Cancer Weekly (2009-06-02)
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