Cancer Gene Therapy
Research on cancer gene therapy detailed by scientists at Pusan National University, Department of Molecular Biology
Published in Cancer Weekly, June 2nd, 2009
New investigation results, 'p53, secreted by K-Ras-Snail pathway, is endocytosed by K-Ras-mutated cells; implication of target-specific drug delivery and early diagnostic marker,' are detailed in a study published in Oncogene. "p53 is eliminated from K-Ras-mutated cancer cells through direct interaction with Snail. However, it is not achieved through proteasome-mediated degradation or transcriptional repression," scientists writing in the journal Oncogene report.
"Here we provide evidence that p53, binding with Snail, is exported from a K-Ras-mutated cell through a vesicle transport-like mechanism, independently using a p53-nuclear-exporting mechanism....
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Source: Cancer Weekly (2009-06-02)
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