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Cancer Gene Therapy
Research on cancer gene therapy detailed by scientists at Pusan National University, Department of Molecular Biology
June 2nd, 2009
New investigation results, 'p53, secreted by K-Ras-Snail pathway, is endocytosed by K-Ras-mutated cells; implication of target-specific drug delivery and early diagnostic marker,' are detailed in a study published in Oncogene. "p53 is eliminated from K-Ras-mutated cancer cells through direct interaction with Snail. However, it is not achieved through proteasome-mediated degradation or transcriptional repression," scientists writing in the journal Oncogene report. "Here we provide evidence that p53, binding with Snail, is exported from a K-Ras-mutated cell through a vesicle transport-like mechanism, independently using a p53-nuclear-exporting mechanism....
Source: Cancer Weekly (2009-06-02)
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