Hepatocellular Cancer
Scientists at University of Munich release new data on hepatocellular cancer
Published in Cancer Weekly, June 2nd, 2009
"cJun terminal kinase (JNK) is constitutively activated in most hepatocellular carcinomas (HCCs), yet its exact role in carcinogenesis remains controversial. While tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known as a major mediator of acquired immune tumour surveillance, and is currently being tested in clinical trials as a novel cancer therapy, the resistance of many tumours to TRAIL and concerns about its toxicity in vivo represent obstacles to its clinical application," scientists in Munich, Germany report.
"In this study we investigated whether JNK activity in HCC could contribute to the resistance to apoptosis in these tumours. The...
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Source: Cancer Weekly (2009-06-02)
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