Cancer Weekly
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Cancer Gene Therapy
Researchers from University Hospital, Department of Dermatology discuss findings in cancer gene therapy
June 2nd, 2009
New investigation results, 'Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer,' are detailed in a study published in Gene Therapy. "Human T lymphocytes can be redirected with a new defined specificity by expression of a chimeric T-cell receptor (immunoreceptor) for the use in adoptive immunotherapy of cancer. Whereas standard procedures use retroviral gene transduction to constitutively express immunoreceptors in T cells, we here explored for the first time mRNA electroporation to achieve transient immunoreceptor expression, and thereby minimizing the risk of persistence of potential...
Source: Cancer Weekly (2009-06-02)
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