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Cancer Vaccines
Center of Molecular Immunology details research in cancer vaccines
June 2nd, 2009
A report, 'Anti-ganglioside anti-idiotypic monoclonal antibody-based cancer vaccine induces apoptosis and antiangiogenic effect in a metastatic lung carcinoma,' is newly published data in Cancer Immunology, Immunotherapy. "Anti-idiotype monoclonal antibody (mAb) 1E10 was generated by immunizing BALB/c mice with an Ab1 mAb which recognizes NeuGc-containing gangliosides, sulfatides and some tumor antigens. 1E10 mAb induces therapeutic effects in a primary breast carcinoma and a melanoma model. However, the tumor immunity mechanisms have not been elucidated," researchers in Havana, Cuba report. "Here we show that aluminum hydroxide-precipitated 1E10 mAb immunization...
Source: Cancer Weekly (2009-06-02)
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