Melanoma
Research on melanoma reported by T. Juhasz et al
Published in Cancer Weekly, June 2nd, 2009
According to a study from Debrecen, Hungary, "The immunosuppressant cyclosporine A (CsA) is a specific pharmacological inhibitor of calcineurin, the Ca2+-calmodulin activated phospho-Ser/Thr-specific protein phosphatase. Although calcineurin-inhibiting compounds are applied for local treatment of psoriasis or atopic dermatitis in dermatological practice, little is known about the functions of calcineurin in epidermis-derived malignancies."
"We investigated the effects of CsA on two human melanoma cell lines, the metastasis forming HT168 and WM35 established from an RGP primary lesion. CsA of 2 mc M lowered the enzyme activity by 50% and caused elevation in both mRNA and...
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Source: Cancer Weekly (2009-06-02)
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