Neuroblastoma

Study data from M. Yu et al provide new insights into neuroblastoma

Published in Cancer Weekly, June 2nd, 2009

According to recent research published in the International Journal of Oncology, "Neuroblastoma shows complex patterns of genetic aberrations including MYCN amplification, deletion of chromosome 1p or 11q, and gain of chromosome 17q. The 17q gain is frequently observed in high-risk neuroblastomas, however, the candidate genes still remain elusive."

"In the present study, we integrated the data of comparative genomic hybridization of 236 tumors by BAC array and expression profiling of 136 tumors by using the in-house cDNA microarray carrying 5,340 genes derived from primary neuroblastomas. A novel candidate gene mapped to chromosome 17q25.1 with two splicing...

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Source: Cancer Weekly (2009-06-02)

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