Neutropenia
Research on neutropenia discussed by scientists at State University of New York
Published in Cancer Weekly, June 2nd, 2009
According to recent research published in the journal Cancer Chemotherapy and Pharmacology, " Our objective was to build a mechanism-based pharmacodynamic model for the time course of neutropenia in cancer patients following paclitaxel treatment with a tocopherol-based Cremophor-free formulation (Tocosol Paclitaxel (R)) and Cremophor (R) EL-formulated paclitaxel (Taxol (R)). A randomized two-way crossover trial was performed with 35 adult patients who received 175 mg/m(2) paclitaxel as either 15 min (Tocosol Paclitaxel) or 3 h (Taxol) intravenous infusions."
"Paclitaxel concentrations were measured by LC-MS/MS. NONMEM VI was used for population pharmacodynamics....
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Source: Cancer Weekly (2009-06-02)
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