Cancer Weekly
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Cancer Gene Therapy
New cancer gene therapy findings from University of Saskatchewan described
June 2nd, 2009
According to recent research from Saskatoon, Canada, "Recombinant adenoviral vectors (AdVTNF-alpha) expressing alpha tumor necrosis factor (TNF-alpha) under control of cytomegalovirus (CMV) promoter have been used in cancer gene therapy. To reduce its cytotoxicity, we constructed a recombinant AdV(TERT)mTNF-alpha expressing a mutant TNF-alpha (mTNF-alpha) with mutations at D142N and A144R under control of human telomerase reverse transcriptase ( hTERT) promoter for treatment of well-established ovalbumin (OVA)-expressing murine B16 melanoma (BL6-10(OVA)) (6mm in diameter)." "We demonstrated that the mTNF-alpha with mutations at D142N and A144R has less in vitro...
Source: Cancer Weekly (2009-06-02)
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