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Vascular Endothelial Growth Factor

Studies from C.C. Lin and co-authors have provided new information about vascular endothelial growth factor

Published in Cancer Weekly, June 2nd, 2009

According to recent research from the United States, " Complex interrelationships exist between the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) receptor pathways. EGFR activation elicits cell proliferation and increased VEGF expression."

"To maximally inhibit EGFR and then downstream VEGF activity, this phase I study was initiated to determine the maximum tolerated dose (MTD) of erlotinib with Wxed-dose cetuximab, and then combine with bevacizumab in patients with advanced malignancies. Patients and methods Patients with advanced malignancies likely to express EGFR were treated with a full dose of cetuximab intravenous weekly,...

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