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Alzheimer Disease
New Alzheimer disease research has been reported by scientists at University of Leuven
June 2nd, 2009
According to a study from Louvain, Belgium, "The gamma-secretase complex plays a role in Alzheimer's disease and cancer progression. The development of clinically useful inhibitors, however, is complicated by the role of the gamma-secretase complex in regulated intramembrane proteolysis of Notch and other essential proteins." "Different gamma-secretase complexes containing different Presenilin or Aph1 protein subunits are present in various tissues. Here we show that these complexes have heterogeneous biochemical and physiological properties. Specific inactivation of the Aph1B gamma-secretase in a mouse Alzheimer's disease model led to improvements of Alzheimer's...
Source: Cancer Weekly (2009-06-02)
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