Cancer Therapy
Scientists at University of Nijmegen, Nijmegen Center for Molecular Life Science detail research in cancer therapy
Published in Cancer Weekly, June 2nd, 2009
Researchers detail in 'Polyinosinic polycytidylic acid prevents efficient antigen expression after mRNA electroporation of clinical grade dendritic cells,' new data in cancer. According to recent research from Netherlands, "Tumor-derived peptides are used frequently as antigen (Ag) source in dendritic cell (DC) therapy in cancer patients. An alternative is to load DC with tumor-associated Ag (TAA)-encoding RNA."
"RNA-loading obviates prior knowledge of CTL and Th epitopes in the Ag. Multiple epitopes for many HLA alleles (both MHC class I and class II) are encoded by the RNA and loading is independent of the patient's HLA make-up. Herein, we determined the optimal...
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Source: Cancer Weekly (2009-06-02)
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