Cancer Gene Therapy

Reports outline cancer gene therapy study findings from University of Navarra

Published in Cancer Weekly, June 2nd, 2009

"Bioluminescent imaging (BLI) is based on the detection of light emitted by living cells expressing a luciferase gene. Stable transfection of luciferase in cancer cells and their inoculation into permissive animals allows the noninvasive monitorization of tumor progression inside internal organs," scientists in Pamplona, Spain report.

"We have applied this technology for the development of a murine model of colorectal cancer involving the liver, with the aim of improving the pre-clinical evaluation of new anticancer therapies. A murine colon cancer cell line stably transfected with the luciferase gene (MC38Luc1) retains tumorigenicity in immunocompetent C57BL/6 animals....

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Source: Cancer Weekly (2009-06-02)

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