Life Sciences
New life sciences study findings have been reported from Cambridge University, Medical Research Council Center for Protein Engineering
Published in Cancer Weekly, June 2nd, 2009
New research, 'Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2,' is the subject of a report. "The transcriptional activity of the tumor suppressor, p53, requires direct binding between its transactivation domain (TAD, 1-57) and the transcriptional coactivator, p300. We systematically assessed the role of TAD phosphorylation on binding of the p300 domains CH3, Taz1, Kix and IBiD," scientists writing in the journal Oncogene report.
"Thr18 phosphorylation increased the affinity up to sevenfold for CH3 and Taz1, with smaller increases from phosphorylation of Ser20, Ser15, Ser37,...
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Source: Cancer Weekly (2009-06-02)
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