Cancer Weekly
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Apoptosis
Study results from M. Furuya et al provide new insights into apoptosis
June 2nd, 2009
According to recent research from Sapporo, Japan, "Survivin, a member of the apoptosis inhibitor family, shows increased expression in human cancers of various origins. It has been demonstrated that survivin inhibits apoptosis via caspase inhibition and promotes mitosis via aurora-B kinase activation." "We recently reported that survivin enhances the expression of human telomerase reverse transcriptase (hTERT), a major determinant of telomerase activity in colon cancer cells. Survivin up-regulates hTERT expression by promoting the expression of specificity protein-1 (Sp1)- and c-Myc-mediated gene transcription via enhancing the phosphorylation of these transcriptional...
Source: Cancer Weekly (2009-06-02)
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