Cancer Weekly
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Cancer Gene Therapy
Research reports from University Hospital provide new insights into cancer gene therapy
June 2nd, 2009
"Mesenchymal stem cells (MSCs) are appealing as gene therapy cell vehicles given their ease of expansion and transduction. However, MSCs exhibit immunomodulatory and proangiogenic properties that may pose a risk in their use in anticancer therapy," scientists in Madrid, Spain report. "For this reason, we looked for a strategy to con. ne MSCs to a determined location, compatible with a clinical application. Human MSCs genetically modified to express luciferase (MSCluc), seeded in a synthetic extracellular matrix (sECM) scaffold (sentinel scaffold) and injected subcutaneously in immunodeficient mice, persisted for more than 40 days, as assessed by bioluminescence imaging...
Source: Cancer Weekly (2009-06-02)
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