Cancer Weekly
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Gene Therapy
New gene therapy study findings have been published by E. Montini and colleagues
June 9th, 2009
According to recent research from Milan, Italy, "gamma-Retroviral vectors (gamma RVs), which are commonly used in gene therapy, can trigger oncogenesis by insertional mutagenesis. Here, we have dissected the contribution of vector design and viral integration site selection (ISS) to oncogenesis using an in vivo genotoxicity assay based on transplantation of vector-transduced tumor-prone mouse hematopoietic stem/progenitor cells." "By swapping genetic elements between gamma RV and lentiviral. vectors (LVs), we have demonstrated that transcriptionally active long terminal repeats (LTRs) are major determinants of genotoxicity even when reconstituted in LVs and that...
Source: Cancer Weekly (2009-06-09)
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