Cancer Weekly
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Cancer Gene Therapy
Scientists at Saitama Cancer Center, Oncology Department describe research in cancer gene therapy
June 9th, 2009
Data detailed in 'Yolk sac tumor but not seminoma or teratoma is associated with abnormal epigenetic reprogramming pathway and shows frequent hypermethylation of various tumor suppressor genes' have been presented. "Germ cell tumors (GCTs) are thought to arise from primordial germ cells (PGCs) that undergo epigenetic reprogramming: erasure of the somatic imprint in the genital ridge, and re-establishment of the sex-specific imprint at gametogenesis in the developing gonad. Previous studies suggested that GCTs show epigenetic patterns reflecting the reprogramming process of PGCs; however, epigenetic alterations of imprinted genes and their relationship with the methylation status of tumor...
Source: Cancer Weekly (2009-06-09)
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