Cancer Weekly
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Adenocarcinoma
Study data from W. Guo and colleagues update understanding of adenocarcinoma
June 9th, 2009
According to recent research from Shijiazhuang, People's Republic of China, "Ras-association domain family 1A (RASSF1A) gene, a candidate tumor suppressor gene, is inactivated in several human tumors, usually by hypermethylation of its promoter region. RASSF1A induces cell cycle arrest through inhibition of cyclin D1 accumulation." "In this work, the promoter methylation status of the RASSF1A in 92 gastric cardia adenocarcinoma (GCA) and corresponding normal tissues were investigated using Methylation-specific PCR (MSP) approach, immunohistochemistry method and RT-PCR were used respectively to examine the protein expression and mRNA expression of RASSF1A in tumors and...
Source: Cancer Weekly (2009-06-09)
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