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Angiogenesis
Investigators at Uppsala University target angiogenesis
June 9th, 2009
According to a study from Uppsala, Sweden, "High-risk neuroblastoma has an overall five-year survival of less than 40%, indicating a need for new treatment strategies such as angiogenesis inhibition. Recent studies have shown that chemotherapeutic drugs can inhibit angiogenesis if administered in a continuous schedule." "The aim of this study was primarily to characterize tumor spread in an orthotopic, metastatic model for aggressive, MYCN-amplified neuroblastoma and secondarily to study the effects of daily administration of the chemotherapeutic agent CHS 828 on tumor angiogenesis, tumor growth, and spread. MYCN-amplified human neuroblastoma cells (IMR-32, 2 x 10(6))...
Source: Cancer Weekly (2009-06-09)
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