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Arrhythmia
Reports outline arrhythmia research from S.B. Ganapathi and colleagues
June 9th, 2009
"Ganapathi SB, Kester M, Elmslie KS. State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy," investigators in the United States report. "Am J Physiol Cell Physiol 296: C701-C710, 2009. First published February 25, 2009; doi:10.1152/ajpcell.00633.2008.-Human ether-a-go-go-related gene ( HERG) potassium channel acts as a delayed rectifier in cardiac myocytes and is an important target for both pro- and antiarrhythmic drugs. Many drugs have been pulled from the market for unintended HERG block causing arrhythmias. Conversely, recent evidence has shown that HERG plays a role in cell proliferation and is overexpressed both in...
Source: Cancer Weekly (2009-06-09)
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