Cancer Weekly
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Basal Cell Cancer
Study data from S. Lanerplamberger and co-authors update knowledge of basal cell cancer
June 9th, 2009
"Sustained Hedgehog (HH) signaling is implicated in basal cell carcinoma of the skin and other types of cancer. Here we show that GLI1 and GLI2, the main transcriptional activators of the HH pathway, directly regulate expression of the activator protein 1 (AP-1) family member JUN, a transcription factor controlling keratinocyte proliferation and skin homeostasis," researchers in Salzburg, Austria report. "Activation of the JUN promoter by GLI is dependent on a GLI-binding site and the AP-1 sites known to be involved in self-activation of JUN. Transcription of JUN is greatly enhanced in the presence of GLI and requires activated JUN protein. GLI2act is a more potent...
Source: Cancer Weekly (2009-06-09)
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