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Researchers from University of Pennsylvania, Medical Department describe findings in life sciences

Published in Cancer Weekly, June 16th, 2009

"Precise wiring of the nervous system depends on coordinating the action of conserved families of proteins that direct axons to their appropriate targets," scientists in the United States report.

"Slit-roundabout repulsion and netrin-deleted in colorectal cancer (DCC) (frazzled) attraction must be tightly regulated to control midline axon guidance in vertebrates and invertebrates, but the mechanism mediating this regulation is poorly defined. Here, we show that the Fra receptor has two genetically separable functions in regulating midline guidance in Drosophila," wrote L. Yang and colleagues, University of Pennsylvania, Medical Department.

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