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Ovarian Cancer

Study results from Medical University of Vienna provide new insights into ovarian cancer

Published in Cancer Weekly, June 16th, 2009

"Mutations in the KRAS gene are one of the most frequent genetic abnormalities in ovarian carcinoma. They are of renewed interest as new epidermal growth factor receptor (EGFR)targeted therapies are being investigated for use in ovarian carcinoma," investigators in Vienna, Austria report.

"As KRAS mutations are associated with poor response and resistance to EGFR-targeting drugs, this study was conducted to obtain more information on the spectrum of KRAS mutations in ovarian carcinoma. The presence of KRAS mutations in codon 12 and 13 was analyzed in frozen and formalin-fixed paraffin-embedded (FFPE) tissue with a low density biochip platform. 381 malignant (29...

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