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Cancer Gene Therapy
Research conducted at Medical College has updated our knowledge about cancer gene therapy
June 16th, 2009
"Transcatheter arterial embolization (TAE) is a standard treatment for unresectable hepatic malignancies. It blocks the arterial blood supply to the tumor, but blockade of the blood supply can be short-lived as collateral blood vessels develop, leading to the failure of TAE," scientists in Harbin, People's Republic of China report. "Here we report that intraportal delivery of adeno-associated viral (AAV) vectors expressing antisense hypoxia-inducible factor-1 alpha (HIF-1 alpha) (AAV-ASHIF) augments TAE to combat hepatocellular carcinoma (HCC). Intraportal delivery of AAV-ASHIF led to long-term localized expression of transgenic ASHIF in rat liver, and suppressed the...
Source: Cancer Weekly (2009-06-16)
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