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New findings in cancer described from University of Pittsburgh

Published in Cancer Weekly, June 23rd, 2009

According to recent research from the United States, "The human inducible nitric oxide synthase (hiNOS) gene is regulated by nuclear factor kappa B (NF-kappa B) and has recently been shown to be a target of the Wnt/beta-catenin pathway. In this study, we tested the hypothesis that Wnt/beta-catenin signaling might regulate cytokine- or tumor necrosis factor a (TNF alpha)-induced hiNOS expression through interaction with NF-kappa B. A cytokine mixture of TNF alpha + interleukin (IL)-1 beta + IFN gamma induced a 2- to 3-fold increase in hiNOS promoter activity in HCT116 and DLD1 colon cells, but produced a 2-fold decrease in SW480 colon cancer cells."

"A similar...

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