Cancer Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Cancer Gene Therapy
Scientists at University of Texas, M.D. Anderson Cancer Center discuss research in cancer gene therapy
June 23rd, 2009
New research, 'Artemis is a negative regulator of p53 in response to oxidative stress,' is the subject of a report. According to recent research published in the journal Oncogene, "Artemis is a multifunctional phospho-protein with roles in V(D)J recombination, repair of double-strand breaks by nonhomologous end-joining and regulation of cell-cycle checkpoints after DNA damage. Here, we describe a new function of Artemis as a negative regulator of p53 in response to oxidative stress in both primary cells and cancer cell lines." "We show that depletion of Artemis under typical culture conditions (21% oxygen) leads to a spontaneous phosphorylation and stabilization...
Source: Cancer Weekly (2009-06-23)
|
