Cancer Weekly
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Cancer Vaccines Immunology
King's College London, King's College London describes research in cancer vaccines immunology
June 23rd, 2009
Fresh data on cancer vaccines are presented in the report 'Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model.' According to recent research from London, the United Kingdom, "Changes in the composition of glycans added to glycoproteins and glycolipids are characteristic of the change to malignancy. Sialyl-Tn (STn) is expressed by 25-30% of breast carcinomas but its expression on normal tissue is highly restricted." "Sialyl-Tn is an O-linked disaccharide that can be carried on various glycoproteins. One such glycoprotein MUC1 is expressed by the vast majority of breast carcinomas. Both STn and MUC1 have been considered as targets for...
Source: Cancer Weekly (2009-06-23)
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