Cancer Weekly
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Cancer Gene Therapy
Findings in cancer gene therapy reported from University of Pennsylvania, Medical Department
June 23rd, 2009
According to a study from the United States, "Human head and neck squamous cell carcinoma (HNSCC) in addition to lung, skin, ovarian, and other cancers overexpress fibroblast growth factor (FGF) receptors on both individual tumor cells and endothelial cells within the tumor microenvironment. The purpose of this study was to investigate whether FGF2-targeted gene therapy could redirect adenoviral vectors encoding the herpes simplex vir-us thymidine kinase gene (Ad-TK) to FGF receptors on tumor and endothelial cells with the intent of improving both the efficiency of transgene expression and the antitumor response." "An Ad-TK vector consisting of a conjugate of FGF2...
Source: Cancer Weekly (2009-06-23)
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