Cancer Weekly
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Leukemia Gene Therapy
Studies conducted at University of Tokyo on leukemia gene therapy recently published
June 23rd, 2009
Fresh data on leukemia are presented in the report 'Pathogenetic significance of ecotropic viral integration site-1 in hematological malignancies.' "The ecotropic viral integration site-1 (Evi-1) gene was first identified as a common locus of retroviral integration in murine leukemia models. In humans, EVI-1 is located on chromosome 3q26, and rearrangements on chromosome 3q26 often activate EVI-1 expression in hematological malignancies," researchers in Tokyo, Japan report. "Overexpression of EVI-1 also occurs with high frequency in leukemia patients without 3q26 abnormalities, and importantly, high EVI-1 expression is an independent negative prognostic indicator...
Source: Cancer Weekly (2009-06-23)
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